Chinese Factory Supply 99% Pure 89226-75-5 Manidipine dihydrochloride with Lowest Price
- Molecular Formula:C35H38N4O6*2ClH
- Molecular Weight:683.632
- Vapor Pressure:1.07E-20mmHg at 25°C
- Melting Point:157-163°; mp 174-180°; mp 167-170°
- Boiling Point:722 °C at 760 mmHg
- Flash Point:390.4 °C
- PSA：116.93000
- LogP:6.48280
Manidipine hydrochloride(Cas 89226-75-5) Usage
Manidipine dihydrochloride is a calcium channel blocker belonging to the dihydropyridine class, primarily used in the treatment of hypertension. It works by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and a subsequent decrease in blood pressure. Manidipine has a long-lasting effect due to its lipophilic nature, allowing for once-daily dosing.
InChI:InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H
89226-75-5 Process route
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- 89226-50-6,120092-68-4,133082-19-6
manidipine
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- 89226-75-5,119992-99-3,126229-12-7,126372-04-1
Manidipine dihydrochloride
Conditions
| Conditions |
Yield |
|
With hydrogenchloride; In methanol; dichloromethane; at 0 - 10 ℃; for 1h; Large scale;
|
81.8% |
|
With hydrogenchloride; In isopropyl alcohol; acetone; pH=1 - 1.5;
|
|
|
With hydrogenchloride; In ipa; acetone; pH=1 - 1.5;
|
|
-
- 841-77-0
diphenylmethylpiperazine
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- 89226-75-5,119992-99-3,126229-12-7,126372-04-1
Manidipine dihydrochloride
Conditions
| Conditions |
Yield |
|
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 20 °C / Reflux
2: dmap; dicyclohexyl-carbodiimide / toluene / 2 h / 20 - 75 °C
3: hydrogenchloride / isopropyl alcohol; acetone / pH 1 - 1.5
With hydrogenchloride; dmap; potassium carbonate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene;
|
|
|
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / Reflux
2: dmap; dicyclohexyl-carbodiimide / toluene / 2 h / 70 - 75 °C
3: hydrogenchloride / ipa; acetone / pH 1 - 1.5
With hydrogenchloride; dmap; potassium carbonate; dicyclohexyl-carbodiimide; In ipa; N,N-dimethyl-formamide; acetone; toluene;
|
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89226-75-5 Downstream products
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