What is the Nepafenac?

Nepafenac is , while it's Molecular Formula is C15H14N2O2. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop. It reduces pain and inflammation in the eyes. Nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery.

What is the CAS number for Nepafenac?

The CAS number of Nepafenac is 78281-72-8.

What is Nepafenac (78281-72-8) used for?

Nepafenac, launched by Alcon Laboratories, is a topical ophthalmic medication indicated for the treatment of ocular pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, which is an NSAID and a potent non-selective inhibitor of COX-1 (IC50=0.25 μM)) and COX-2 (IC50=0.15μM). Nepefenac itself exhibits only weak activity against COX-1 (IC50=64.3μM). Amfenac (Fenazox) has been marketed in Japan since 1986 for the treatment of rheumatoid arthritis, post-surgical pain, and inflammation. With most NSAIDs that are currently being used as topical ophthalmic agents, the maximum drug concentration is achieved on the ocular surface, with progressively lower concentrations in the cornea, aqueous humor, vitreous, and retina. Nepafenac has been found to have a penetration coefficient that is 4-28 times greater than that achieved with conventional NSAIDs such as diclofenac, bromofenac, and ketorolac. In addition, the bioconversion of nepefenac to amfenac is primarily mediated by ocular tissue hydrolases, specifically in the iris, ciliary body, retina, and choroid. The enhanced permeability of nepefenac combined with rapid bioactivation in the ocular tissue translates into superior anti-inflammatory efficacy at the target sites.InChI:InChI=1/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

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Nepafenac

Product Name: Nepafenac
CasNo: 78281-72-8
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CasNo： 78281-72-8

Molecular Formula： C₁₅H₁₄N₂O₂

Reputable Factory Supply 99% Pure Nepafenac 78281-72-8 with Safe Delivery

Molecular Formula:C15H14N2O2
Molecular Weight:254.288
Vapor Pressure:1.11E-12mmHg at 25°C
Melting Point:177-181oC
Refractive Index:1.641
Boiling Point:562.5 °C at 760 mmHg
Flash Point:294 °C
PSA：86.18000
Density:1.249 g/cm³
LogP:2.80910

Nepafenac(Cas 78281-72-8) Usage

Nepafenac eye drops is used to treat pain and swelling of the eye following cataract surgery. This medicine is a topical nonsteroidal anti-inflammatory drug (NSAID). This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Suspension. Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine Valley Industrial Park, Gaoqing County, Zibo City.

InChI:InChI=1/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

78281-72-8 Downstream products

51135-38-7
7-benzoyl-1,3-dihydroindol-2-one
1246956-18-2
2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}acetamide

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